價格 | ¥20200 |
包裝 | 1mg |
最小起訂量 | 1mg |
發(fā)貨地 | 上海 |
更新日期 | 2024-12-02 |
中文名稱:TGFBR1, Mouse, 重組蛋白 (hFc) | 英文名稱:TGFBR1 Protein, Mouse, Recombinant (hFc) |
品牌: TargetMol | 產(chǎn)地: 美國 |
保存條件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month | Shipping with blue ice. | 產(chǎn)品類別: 抑制劑 |
貨號: TMPJ-01178 |
名稱 | TGFBR1 Protein, Mouse, Recombinant (hFc) |
描述 | TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development. |
存儲條件 | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month | Shipping with blue ice. |
關鍵字 | ACVRLK 4 | SKR 4 | TGF-b receptor type I | ALK5 | ACVRLK-4 | SKR-4 | AAT 5 | TGFBR-1 | AAT-5 | TGFR 1 | TGFR1 | ALK 5 | TGFBR 1 |
成立日期 | 2013-04-18 (12年) | 注冊資本 | 589.8595萬人民幣 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 中間體,天然產(chǎn)物,生物化工,化學試劑,生物技術服務 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務 |
產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
---|---|---|---|---|
詢價 |
VIP2年
|
北京百普賽斯生物科技股份有限公司
|
2024-12-16 | |
¥2948 |
VIP4年
|
上海博爾森生物科技有限公司
|
2025-01-03 | |
¥2100 |
VIP6年
|
上海澤葉生物科技有限公司
|
2025-01-03 |