化合物 Tubulin polymerization-IN-14,Tubulin polymerization-IN-14

化合物 Tubulin polymerization-IN-14|T60600|TargetMol

價(jià)格	￥13800	￥17500	￥10600
包裝	50mg	100mg	25mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

QQ交談微信洽談

產(chǎn)品詳情

中文名稱:化合物 Tubulin polymerization-IN-14	英文名稱:Tubulin polymerization-IN-14
CAS:2417134-05-3	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號: T60600

Product Introduction

Bioactivity

Name	Tubulin polymerization-IN-14
Description	Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor (IC 50 = 3.15 μM) that exhibits potent anti-vascular and anticancer activities including cancer cell apoptosis [1].
In vitro	Tubulin polymerization-IN-14 (Compound 20a) binds to the colchicine binding site on tubulin [1]. Tubulin polymerization-IN-14 (0-1 μM; 72 h) inhibits cancer cell growth [1]. Tubulin polymerization-IN-14 (5-20 nM; 48 h) arrests K562 cell cycle at G2/M phase, significantly induces cell apoptosis in K562 cells in a concentration-dependent manner, and induces mitochondrial membrane potential (MMP) collapse and mitochondrial dysfunction in K562 cells [1]. Tubulin polymerization-IN-14 (5-20 nM; 24 h) significantly decreases wound closure and capillary-like tubules formation in a concentration-dependent manner in HUVECs [1]. Cell Proliferation Assay [1] Cell Line: K562 cells Concentration: 0-1 μM Incubation Time: 72 h Result: Showed anti-proliferative activity with an IC 50 of 0.01 ± 0.001 μM against K562 cells. Cell Cytotoxicity Assay [1] Cell Line: HepG2, HCT-8, MDA-MB-231 and HFL-1 cells Concentration: 0-1 μM Incubation Time: 72 h Result: Showed cytotoxic activities with IC 50 s of 0.019 ± 0.002, 0.021 ± 0.003, 0.02 ± 0.001 and 0.118 ± 0.007 μM against HepG2, HCT-8, MDA-MB-231 and HFL-1 cells, respectively. Cell Cycle Analysis [1] Cell Line: K562 cells Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 48 h Result: 9.40%, 11.54% and 15.28% of cells were arrested at G2/M phase at 5, 10 and 20 nM, respectively. Apoptosis Analysis [1] Cell Line: K562 cells Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 48 h Result: Compared to the percentage of apoptosis cells in control group (3.25%), the total percentage of the early (Annexin-Vt/PI) and late (Annexin-Vt/PIt) apoptosis cells were 10.46%, 48.55% and 62.26% after being treated at 5, 10, and 20 nM for 48 h, respectively. Cell Migration Assay [1] Cell Line: HUVECs Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 24 h Result: After exposed to compound at 5, 10, and 20 nM for 24 h, cells migrated into 67.6%, 55.3% and 49.2% of the wound area, respectively.
In vivo	Tubulin polymerization-IN-14 (Compound 20a) (15 and 30 mg/kg; i.v.; daily for 21 days) displays obvious and dose-dependent antitumor effect with no significant toxicity in the liver tumor allograft mouse model [1]. Animal Model: Five-week-old male ICR mice, liver tumor allograft model [1] Dosage: 15 and 30 mg/kg Administration: Intravenous injection, daily for 21 days Result: The decrease in tumor weight reached 68.7% at doses of 30 mg/kg per day at 21 days after initiation of treatment as compared to vehicle without obvious loss of body weight.
Storage	Shipping with blue ice.

關(guān)鍵字： Tubulin polymerization-IN-14|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊資本	589.8595萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	中間體,天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 1年

公司成立：12年
注冊資本：589.8595萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：抑制劑&激動(dòng)劑，天然產(chǎn)物，重組蛋白，化合物庫，技術(shù)服務(wù)
公司地址：上海市靜安區(qū)江場三路238號8樓

進(jìn)入店鋪

詢盤

店內(nèi)推薦

化合物 AM-8553|T23713|TargetMol

￥19400

化合物 Azido-PEG5-triethoxysilane|T17517|TargetMol

￥387

化合物 Nevirapine hemihydrate|T69796|TargetMol

￥13800