化合物 GSK2879552|T3677|TargetMol

1篇文獻(xiàn)

價(jià)格	￥793	￥389
包裝	5mg	2mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-12

QQ交談微信洽談

產(chǎn)品詳情

中文名稱:化合物 GSK2879552	英文名稱:GSK2879552
CAS:1401966-69-5	品牌: TargetMol
產(chǎn)地: 美國	保存條件: store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.22%	產(chǎn)品類別: 抑制劑
貨號(hào): T3677

Product Introduction

Bioactivity

Name	GSK2879552
Description	GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity.
Cell Research	The optimal cell seeding is determined empirically for all cell lines by examining the growth of a wide range of seeding densities in a 384-well format to identify conditions that permitted proliferation for 6?days. Cells are then plated at the optimal seeding density 24?h before treatment (in duplicate) with a 20-point twofold dilution series of GSK2879552 or 0.15% DMSO. Plates are incubated for 6?days at 37°C in 5% CO2. Cells are then lysed with CellTiter-Glo (CTG) (Promega) and chemiluminescent signal is detected with a TECAN Safire2 microplate reader. In addition, an untreated plate of cells is harvested at the time of compound addition (T0) to quantify the starting number of cells. CTG values obtained after the 6?day treatment are expressed as a percent of the T0 value and plotted against compound concentration. Data are fit with a four-parameter equation to generate a concentration response curve and the concentration of GSK126 required to inhibit 50% of growth (growth IC50) is determined.(Only for Reference)
Kinase Assay	LSD1 enzyme assay: LSD1 activity was measured using a horseradish peroxidase (HRP) coupled assay with amplex red as an electron donor. The formation of product over time is measured using fluorescence intensity, Ex 531 nm and Em 595 nm, in a PerkinElmer EnVision plate reader. Final assay conditions are: 5 nM LSD1, 2.5 μM H3K4me2 peptide, 50 mM HEPES pH 7, 1 U/ml of HRP, 1 mM CHAPS, 0.03% dBSA and 10 μM amplex red.
In vitro	在165個(gè)細(xì)胞系中，GSK2879552對(duì)9/28個(gè)小細(xì)胞肺癌(SCLC)系和20/29個(gè)AML系的生長抑制率在40%至100%之間。對(duì)于對(duì)GSK2879552產(chǎn)生生長抑制反應(yīng)的SCLC細(xì)胞系和初級(jí)樣本子集，顯示出一組特征探針的DNA低甲基化。[1]
In vivo	在攜帶SCLC異種移植瘤的小鼠中，GSK2879552（1.5 mg/kg，p.o.）展現(xiàn)了17%-83%的腫瘤生長抑制效果。[1]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : <1 mg/mL DMSO : 27 mg/mL (74.1 mM)
Keywords	Inhibitor \| inhibit \| Histone Demethylase \| GSK-2879552 \| GSK2879552 \| GSK 2879552
Inhibitors Related	DDP-38003 dihydrochloride \| Zavondemstat \| FY-21 \| KDM4-IN-4 \| Procaine hydrochloride \| JIB-04 \| GSK-J4 \| LSD1-IN-24 \| Daminozide \| AS8351 \| GSK-LSD1 dihydrochloride \| Tranylcypromine hemisulfate

關(guān)鍵字： GSK 2879552 HCl|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.265100萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 3年

公司成立：12年
注冊(cè)資本：566.265100萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場(chǎng)三路238號(hào)8樓

進(jìn)入店鋪

詢盤

店內(nèi)推薦

N-甲基蕓香堿|TN4614|TargetMol

￥1080

化合物 GZD824 Dimesylate|T2429|TargetMol

￥329

匹可硫酸鈉一水合物|T3286|TargetMol

￥115