Human Activin RIIA / ACVR2A Protein, Fc Tag
分子別名(Synonym)
Activin receptor type IIA,ACTRIIA
表達區(qū)間及表達系統(tǒng)(Source)
Human ACVR2A, Fc Tag (ACA-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1).
Predicted N-terminus: Pro
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
激活素受體2A型(ACVR2A)也稱為激活素ⅡA型、ACTR-IIA、ACTRIIA和ACVR2,ACVR2是單程I型膜蛋白。ACVR2A屬于蛋白激酶超家族、TKL-Ser/Thr蛋白激酶家族和TGFB受體亞家族。在配體結(jié)合上,ACVR2A可以形成由兩種II型和兩種I型跨膜絲氨酸/蘇氨酸激酶組成的受體復(fù)合物。II型受體磷酸化并激活I型受體,I型受體自身磷酸化,然后結(jié)合并激活SMAD轉(zhuǎn)錄調(diào)節(jié)因子。ACVR2A也是激活素A、激活素B和抑制素A的受體。已經(jīng)鑒定出幾種I I型激活素受體,它們以不同的親和力與不同的激活素結(jié)合。
關(guān)鍵字: Activin RIIA;ACVR2A;ACVR2A蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。