酮麝香|T5654|TargetMol

價(jià)格	￥435	￥196	￥122
包裝	500mg	100mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:酮麝香	英文名稱:Musk ketone
CAS:81-14-1	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.85%	產(chǎn)品類別: 抑制劑
貨號(hào): T5654

Product Introduction

Bioactivity

名稱	Musk ketone
描述	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.
細(xì)胞實(shí)驗(yàn)	Twenty two cancer cell lines were treated with musk. Cell proliferation and apoptosis analyses were carried out. Native musk and synthetic?musk ketone?were analyzed by gas chromatograph-mass spectrometer (GC-MS) assay. Differentially expressed genes were determined by microarray and quantitative real-time polymerase chain reaction.
動(dòng)物實(shí)驗(yàn)	The rats weighed from 200 to 250 g and ?were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).?The Swash plate test and BBB behavioral score were used to determine neurological function recovery after spinal cord injury.?Hematoxylin-eosin (HE) staining was used to detect general structural changes in spinal cord tissue.?The enzyme-linked immunosorbent assay was used for the determination of interleukin 10 (IL-10) in spinal cord tissue.??Compared with the NS control group, critical angle, BBB score and IL-10 levels in rat spinal cord tissue significantly increased in the MP group and MO groups 7 and 14 days after the operation.?HE staining showed that in the NS group, there was hemorrhage, edema, necrosis, axonal demyelination, inflammatory cell infiltration and glial cell response in spinal cord tissue.?After 7 days, spinal cord edema and inflammation were reduced and neuronal degeneration and necrosis were not evident in the MP and MO groups[2].
體外活性	類似于天然麝香，合成Musk ketone抑制了癌細(xì)胞的生長(zhǎng)并促進(jìn)了其凋亡。此外，天然麝香處理后的肺癌細(xì)胞中許多基因表達(dá)發(fā)生了變化，這些差異表達(dá)的基因涉及多個(gè)信號(hào)傳導(dǎo)途徑。在這些信號(hào)途徑中，與凋亡相關(guān)的途徑包括白細(xì)胞介素家族、腫瘤壞死因子家族和MAPK信號(hào)途徑。天然麝香和合成Musk ketone能夠在肺癌細(xì)胞中上調(diào)IL-24（白細(xì)胞介素家族）和DDIT3（MAPK信號(hào)途徑）[1]。
體內(nèi)活性	Musk ketone可減少脊髓損傷后的次生損害，并促進(jìn)大鼠神經(jīng)恢復(fù)[2]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 25 mg/mL (84.95 mM)
關(guān)鍵字	Apoptosis \| inhibit \| Hep G2 \| PI3K/Akt \| Musk ketone \| neuroprotective \| Protein kinase B \| Inhibitor \| PKB \| cerebral ischemia \| PI3K \| Akt \| Phosphoinositide 3-kinase
相關(guān)庫(kù)	神經(jīng)保護(hù)化合物庫(kù) \| 抗癌活性化合物庫(kù) \| 經(jīng)典已知活性庫(kù) \| 已知活性化合物庫(kù) \| 抗癌天然產(chǎn)物庫(kù) \| 天然產(chǎn)物庫(kù) \| 化妝品成分化合物庫(kù) \| 高通量篩選天然產(chǎn)物庫(kù)

關(guān)鍵字：酮麝香|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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