化合物Angiotensin 1-7|T7339|TargetMol

價格	￥243	￥428	￥672
包裝	2mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-03-12

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產(chǎn)品詳情

中文名稱:化合物Angiotensin 1-7	英文名稱:Angiotensin (1-7)
CAS:51833-78-4	品牌: TargetMol
產(chǎn)地: 美國	保存條件: keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 100%	產(chǎn)品類別: 抑制劑
貨號: T7339

Product Introduction

Bioactivity

名稱	Angiotensin (1-7)
描述	Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activities.
細胞實驗	Cultured cardiomyocytes were treated with PBS (control), ANG II (100 nM), ANG-(1–7) (100 nM), ANG II + ANG-(1–7), ANG II + ANG-(1–7) + A779 (10 μM), ANG II + ANG-(1–7) + Sirt3 short hairpin (sh)RNA, lentiviral particles (1 × 10^6 TU) containing a Sirt3 shRNA viral vector, or ANG II + Mito-TEMPO (0.1 μM) for 24 h. Each treatment was performed in triplicate wells. Monoclonal anti-α-sarcomeric actin antibody was used for identification and measurement of cardiomyocytes via immunofluorescence staining. Cells were fixed in methanol at ?10°C and washed with fresh washing solution (0.1% Triton X-100 in PBS) three times. After preincubation with 3% BSA for 20 min, cells were incubated with primary antibody, which was diluted to 1:100 with PBS containing 3% BSA, overnight at 4°C. After three washings with the washing solution, cells were incubated with fluorescence-conjugated anti-mouse IgG (1:500 diluted in PBS) for 1 h at room temperature. Photographic images of cardiomyocytes were taken with a fluorescence microscope. Image-analysis software was used to measure the cell surface area of cardiomyocytes that were positively stained for sarcomeric actin. Variations in cell size were expressed as relative cell surface area versus the control. At least 50 cells in each dish were randomly selected for surface area analysis[1].
動物實驗	Eighteen dogs were randomly assigned to sham group, pacing group and Ang-(1-7) group. Rapid atrial pacing was maintained for 14 days in the pacing and Ang-(1-7) groups. Ang-(1-7) was administered intravenously in the Ang-(1-7) group. The atrial effective refractory period and atrial fibrillation inducibility level were measured at baseline and under sympathetic nerve stimulation after 14 days of measurement. The atrial sympathetic nerves labeled with tyrosine hydroxylase were detected using immunohistochemistry and Western blotting, and tyrosine hydroxylase and nerve growth factor mRNA levels were measured by reverse transcription polymerase chain reaction[2].
體外活性	ANG-(1-7)顯著減輕了ANG II引起的大鼠心臟肥大和周血管纖維化。這些ANG-(1-7)的效果在培養(yǎng)的心肌細胞中得到了證實，其中ANG-(1-7)顯著減輕了ANG II引導的細胞大小增加[1]。
體內(nèi)活性	Ang-(1-7)處理減輕了心房有效不應期的縮短和心房顫動誘導能力水平的增加。免疫組化和Western blotting結(jié)果顯示，起搏組存在交感神經(jīng)過度增生，而Ang-(1-7)減輕了交感神經(jīng)的增殖。Ang-(1-7)緩解了起搏引起的酪氨酸羥化酶及神經(jīng)生長因子mRNA表達水平的增加[2]。
存儲條件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 8.99 mg/ml (10 mM)
關鍵字	Endogenous Metabolite \| Angiotensin Receptor \| Angiotensin (17) \| Ang \| Inhibitor \| Angiotensin (1-7) \| inhibit \| Angiotensin \| Angiotensin (1 7) \| Angiotensin-converting Enzyme (ACE)
相關產(chǎn)品	Oleamide \| p-Hydroxybenzaldehyde \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Oxalic acid dihydrate \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
相關庫	抑制劑庫 \| 經(jīng)典已知活性庫 \| 已知活性化合物庫 \| ReFRAME 相關化合物庫 \| 抗衰老化合物庫 \| 多肽分子庫 \| 內(nèi)分泌激素分子庫 \| 抗高血壓化合物庫 \| 膜蛋白靶向化合物庫 \| 人代謝物化合物庫

關鍵字： ASP-ARG-VAL-TYR-ILE-HIS-PRO|||Angiotensin 1-7|||Ang-(1-7)|TargetMol

公司簡介

上海陶術生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學研究的科學家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務。公司下設篩選事業(yè)部，化學事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實體化合物分子供應；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點的分子篩選到對明確分子的多靶點篩選，從高通量篩選到化學結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術服務的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領域優(yōu)秀的供應商，為超過五百家學校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	化學試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務

TargetMol中國（陶術生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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化合物Angiotensin 1-7|T7339|TargetMol相關廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
多肽廠家出售血管緊張素1-7/Angiotensin (1-7)/51833-78-4	￥62	VIP5年	杭州固拓生物科技有限公司	2025-04-03
多肽合成\51833-78-4\Angiotensin(1-7)	詢價	VIP4年	南京源肽生物科技有限公司	2025-04-02
Angiotensin (1-7)	詢價		上海伯易生物科技有限公司	2025-03-27
Angiotensin (1-7	￥1274		上海浩洋生物科技有限公司	2025-03-27
Angiotensin (1-7)	￥924		北京樂博生物科技有限公司	2025-03-27
Angiotensin (1-7)	詢價		上海本瑞生物科技有限公司	2025-03-27
Angiotensin (1-7)	￥550		上海偉寰生物科技有限公司	2025-03-27
Angiotensin 1-7	詢價		上海煊翎生物科技有限公司	2025-03-24
Angiotensin (1-7)	￥648		上海意杰生物科技有限公司	2025-03-24
血管緊張素1-7/Angiotensin (1-7)/51833-78-4	￥200	VIP3年	上海鴻肽生物科技有限公司	2025-03-07

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