Human PDGF-AA Protein, premium grade
分子別名(Synonym)
PDGF-A, PDGF1
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Human PDGF-AA Protein, premium grade (PDA-H5113) is expressed from E. coli cells. It contains AA Ser 87 - Thr 211 (Accession # P04085-1).
Predicted N-terminus: Met
它是在我們嚴(yán)格的質(zhì)量控制體系下生產(chǎn)的,該體系包含一套全面的測(cè)試,包括無(wú)菌和內(nèi)毒素測(cè)試。在早期臨床前階段,產(chǎn)品性能經(jīng)過(guò)仔細(xì)驗(yàn)證和測(cè)試,以確保其與細(xì)胞培養(yǎng)用途或任何其他應(yīng)用的兼容性。當(dāng)準(zhǔn)備過(guò)渡到后期臨床階段時(shí),我們還提供定制的GMP蛋白質(zhì)服務(wù),以滿足您的需求。我們將與您合作,根據(jù)您的要求定制和開(kāi)發(fā)GMP級(jí)產(chǎn)品,該產(chǎn)品也符合細(xì)胞療法細(xì)胞制造中使用的原材料和輔助材料的要求。
蛋白結(jié)構(gòu)(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 14.4 kDa. The protein migrates as 30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
宿主蛋白殘留(Host Cell Protein)
<0.5 ng/μg of protein tested by ELISA.
宿主核酸殘留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
無(wú)菌(Sterility)
Negative
支原體(Mycoplasma)
Negative.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 10 mM Tris, 150 mM NaCl, 30% ACN with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. PDGF can exist either as PDGF-BB or as PDGF-AB or as PDGF-AA where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.PDGF-AA Protein binds to FDGFR and has the potential to enhance bone healing.
關(guān)鍵字: PDGF-AA;PDGF-AA蛋白;PDGF-AA重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。