APC-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag, premium grade (Site-specific conjugation)
分子別名（Synonym）
CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
APC-Labeled Human CLEC12A Protein, His Tag, premium grade (CLA-HA246) is produced via conjugation of APC to Human CLEC12A Protein, His Tag, premium grade with a new generation site-specific technology under optimal conditions with a proprietary technology. Human CLEC12A Protein, His Tag, premium grade is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).
Predicted N-terminus: Gly
該產(chǎn)品是在我們嚴(yán)格的質(zhì)量控制體系下生產(chǎn)的，該體系包含一套全面的測(cè)試，包括無菌和內(nèi)毒素測(cè)試。在早期臨床前階段，產(chǎn)品性能經(jīng)過仔細(xì)驗(yàn)證和測(cè)試，以確保其與細(xì)胞培養(yǎng)用途或任何其他應(yīng)用的兼容性。當(dāng)準(zhǔn)備過渡到后期臨床階段時(shí)，我們還提供定制的GMP蛋白質(zhì)服務(wù)，以滿足您的需求。我們將與您合作，根據(jù)您的要求定制和開發(fā)GMP級(jí)產(chǎn)品，該產(chǎn)品也符合細(xì)胞療法細(xì)胞制造中使用的原材料和輔助材料的要求。
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 27.3 kDa.
偶聯(lián)（Conjugate）
APC
Excitation Wavelength: 640 nm
Emission Wavelength: 661 nm
應(yīng)用說明（Application）
Please note that this product is NOT compatible to streptavidin detection system.
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per test by the LAL method.
無菌（Sterility）
Negative
支原體（Mycoplasma）
Negative.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, 0.5% rHSA, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution;
2-8°C for 12 months under sterile conditions after reconstitution.
背景（Background）
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
關(guān)鍵字： CLEC12A;CLEC12A蛋白;CLEC12A重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。