價格 | 詢價 | ||
包裝 | 100ug | 500ug | 1000ug |
最小起訂量 | 100ug |
發(fā)貨地 | 北京 |
更新日期 | 2025-01-20 |
中文名稱:IL23A & IL12B蛋白 | 英文名稱:IL23A & IL12B |
品牌: 百普賽斯 | 產(chǎn)地: 北京 |
保存條件: -20°C to -70°C | 純度規(guī)格: 99.9% |
產(chǎn)品類別: 重組蛋白 | |
貨號: IL23A & IL12B | 用途范圍: 藥物開發(fā)等 |
規(guī)格: 100ug | 是否進口: 否 |
靶點: IL23A & IL12B | 種屬: Mouse |
表達系統(tǒng): HEK293 |
分子別名(Synonym)
IL-23 alpha & IL-12 beta
表達區(qū)間及表達系統(tǒng)(Source)
Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-M52W7) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9EQ14-1 (IL23A) & P43432-1 (IL12B)).
Predicted N-terminus: His (IL23A) & Met 23 (IL12B)
蛋白結(jié)構(gòu)(Molecular Characterization)
Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23A and IL-12B, has a calculated MW of 20.5 kDa (IL-23A) and 35.8 kDa (IL-12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12B contains no tag. The reducing (R) protein migrates as 20 kDa (IL-23A) and 45 kDa (IL-12B) respectively due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白細胞介素-23亞基α(IL-23α)可以與IL12B結(jié)合形成IL-23白細胞介蛋白,這是一種異二聚體細胞因子,在先天免疫和適應性免疫中起作用。IL-23可能與IL-17共同構(gòu)成外周組織對感染的急性反應。IL-23與由IL12RB1和IL23R組成的異二聚體受體復合物結(jié)合,激活Jak-Stat信號級聯(lián),刺激記憶而不是幼稚T細胞,并促進促炎細胞因子的產(chǎn)生。IL-23誘導自身免疫性炎癥,因此可能是自身免疫性炎性疾病的原因,可能對腫瘤發(fā)生很重要。
成立日期 | 2010-07-22 (15年) | 注冊資本 | 8000萬人民幣 |
員工人數(shù) | 500人以上 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 醫(yī)藥中間體,原料藥,激素類,氨基糖苷類,中樞神經(jīng)系統(tǒng)用藥 | 經(jīng)營模式 | 工廠,試劑 |
產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
---|---|---|---|---|
¥1680.00 |
VIP9年
|
北京索萊寶科技有限公司
|
2025-02-07 | |
¥3320 |
VIP4年
|
上海博爾森生物科技有限公司
|
2025-01-17 | |
¥2928 |
VIP6年
|
上海澤葉生物科技有限公司
|
2025-01-20 |