Product Name：Myelin Basic Protein (85-99) peptide antagonist
CAS No.：444305-16-2
Synonyms：免疫顯性表位多肽
Catalog No.：176P06
Brand：HongTide（上海鴻肽生物）
Description：Myelin Basic Protein (85-99) peptide antagonist是拮抗性多肽與 MBP (85-99) 競爭，MBP (85-99) 是髓鞘堿性蛋白 (MBP) 的免疫顯性表位，是多發(fā)性硬化癥 (MS) 中的主要候選自身抗原，與人類白細胞抗原 (HLA)-DR2 結合，是由15個氨基酸組成的多肽。該肽還抑制 MBP (85-99) 特異性 T 細胞克隆分泌 IL-2 并誘導脾細胞產生 Th2 細胞因子。 此外，可以證明該肽能夠以與無規(guī)氨基酸共聚物（例如 Copaxone [poly (Y,E,A,K)n] 等隨機氨基酸共聚物等效的方式）在幾種模型中抑制實驗性自身免疫性腦脊髓炎 (EAE) . 因此，這種合成肽可能適用于 MS 的研究。
Myelin Basic Protein (85-99) peptide antagonist is an antagonistic peptide that competes with MBP (85-99), which is an immune dominant epitope of myelin basic protein (MBP) and a major candidate self antigen in multiple sclerosis (MS). It binds to human leukocyte antigen (HLA) - DR2 and is a peptide composed of 15 amino acids. This peptide also inhibits the secretion of IL-2 by MBP (85-99) - specific T cell clones and induces the production of Th2 cytokines by spleen cells. In addition, it can be demonstrated that the peptide can inhibit experimental autoimmune encephalomyelitis (EAE) in several models in an equivalent manner to random amino acid copolymers such as Copaxone [poly (Y, E, A, K) n]. Therefore, this synthetic peptide may be suitable for the study of MS.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | EKPKVEAYKAAAAPA |
Sequence(3-letter code) | H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH |
Peptide Structure | 
|
Molecular Formula | C70H114N18O21 |
Molecular Weight | 1543.78 |
訂購聯(lián)系方式：
上海鴻肽生物科技有限公司
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郵箱：sales1@hongtide.com
本產品僅供科研使用。
關鍵字： 免疫顯性表位多肽;444305-16-2;Myelin Basic Protein;多肽生產工廠;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產品研發(fā)、生產、銷售以及技術轉讓為主要業(yè) 務科技公司。公司現(xiàn)有產品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質量作船， 以服務為帆，為科研服務”的企業(yè)理念，為國內外眾多科研工作者提供了優(yōu)質的服務及產品。