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DOTA.SA.FAPI,DOTA.SA.FAPI
  • DOTA.SA.FAPI,DOTA.SA.FAPI

DOTA.SA.FAPI

價格 詢價
包裝 10mg 100mg
最小起訂量 1mg
發(fā)貨地 江西
更新日期 2024-12-26
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產(chǎn)品詳情

中文名稱:DOTA.SA.FAPI英文名稱:DOTA.SA.FAPI
品牌: TanzhenBio產(chǎn)地: 江西
保存條件: -20℃純度規(guī)格: 98%
產(chǎn)品類別: 放射顯影多肽產(chǎn)品
是否進口:
2024-12-26 DOTA.SA.FAPI DOTA.SA.FAPI 10mg/RMB;100mg/RMB TanzhenBio 江西 -20℃ 98% 放射顯影多肽產(chǎn)品

Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclinical study with [68Ga]Ga-DOTA.SA.FAPi, the first patient studies were realized for both compounds. Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA5 chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. For this molecule (AAZTA5.SA.FAPi), complexation with radionuclides such as gallium-68, scandium-44, and lutetium-177 was investigated, and the in vitro properties of the complexes were characterized and compared with those of DOTA.SA.FAPi. AAZTA5.SA.FAPi and its derivatives labelled with non-radioactive isotopes demonstrated similar excellent inhibitory potencies compared to the previously published SA.FAPi ligands, i.e., sub-nanomolar IC50 values for FAP and high selectivity indices over the serine proteases PREP and DPPs. Labeling with all three radiometals was easier and faster with AAZTA5.SA.FAPi compared to the corresponding DOTA analogue at ambient temperature. Especially, scandium-44 labeling with the AAZTA derivative resulted in higher specific activities. Both DOTA.SA.FAPi and AAZTA5.SA.FAPi showed sufficiently high stability in different media. Therefore, these FAP inhibitor agents could be promising for theranostic approaches targeting FAP.


關鍵字: 3049080-09-0;DOTA.SA.FAPI;

公司簡介

南昌探真生物技術有限公司 主要業(yè)務:多肽服務 ,肽核酸合成
成立日期 2019-02-05 (6年) 注冊資本 300萬人民幣
員工人數(shù) 10-50人 年營業(yè)額 ¥ 100萬-300萬
主營行業(yè) 生物活性小分子,有機合成試劑,氨基糖苷類 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 南昌探真生物技術有限公司
VIP 5年
  • 公司成立:6年
  • 注冊資本:300萬人民幣
  • 企業(yè)類型:生產(chǎn)型
  • 主營產(chǎn)品:多肽, 放射顯影化合物
  • 公司地址:江西省南昌市小藍經(jīng)濟技術開發(fā)區(qū)匯仁大道266號18棟1樓
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