Product Name：RS17
CAS No.：N/A
Synonyms：抗腫瘤肽RS17
Catalog No.：218P911
Brand：HongTide（上海鴻肽生物）
Description：RS17 是一種設(shè)計(jì)合成的抗腫瘤肽，是由17個(gè)氨基酸組成的多肽，能夠特異性地結(jié)合到 CD47 分子上，阻斷 CD47 與其在巨噬細(xì)胞表面膜上的配體 SIRPα 之間的相互作用。RS17 的主要調(diào)節(jié)機(jī)制是通過(guò)與 CD47 的結(jié)合，阻止 CD47 向 SIRPα 傳遞選擇性吞噬的信號(hào)，這樣巨噬細(xì)胞就不會(huì)將腫瘤細(xì)胞識(shí)別為自身組織，而是將其作為外來(lái)物質(zhì)進(jìn)行吞噬，從而抑制腫瘤細(xì)胞的免疫逃逸。RS17 可用于抗腫瘤反應(yīng)和免疫逃逸機(jī)制的研究。
RS17 is a designed and synthesized anti-tumor peptide, a polypeptide composed of 17 amino acids, which can specifically bind to CD47 molecule and block the interaction between CD47 and its ligand SIRP α on the macrophage surface facial mask. The main regulatory mechanism of RS17 is to bind to CD47, preventing CD47 from transmitting selective phagocytic signals to SIRP α. This way, macrophages will not recognize tumor cells as their own tissue, but instead engulf them as foreign substances, thereby inhibiting tumor cell immune escape. RS17 can be used for the study of anti-tumor response and immune escape mechanisms.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | RRYKQDGGWSHWSPWSS-NH2 |
Sequence(3-letter code) | H-Arg-Arg-Tyr-Lys-Gln-Asp-Gly-Gly-Trp-Ser-His-Trp-Ser-Pro-Trp-Ser-Ser-NH2 |
Peptide Structure | 
|
Molecular Formula | C96H131N31O25 |
Molecular Weight | 2119.26 |
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關(guān)鍵字： RS17;抗腫瘤肽RS17;抗腫瘤肽;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。