米卡芬凈鈉|T1794|TargetMol

價(jià)格	￥253	￥353	￥622
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱(chēng):米卡芬凈鈉	英文名稱(chēng):Micafungin sodium
CAS:208538-73-2	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.63%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T1794

Product Introduction

Bioactivity

名稱(chēng)	Micafungin sodium
描述	Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.
細(xì)胞實(shí)驗(yàn)	Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24?h at 30°C.?Cryptococcus neoformans?YC203 is grown in YM broth medium for 20?h at 30°C with shaking at 200?r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline.?A. fumigatus?FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with?l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165?m?MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105?CFU/well, and the plates are then incubated for 20?h or 48?h at 37°C. Two end points are determined by microscopic observation: MEC, which is defined as a substantial reduction in fungal growth, and MIC, which is defined as a complete inhibition of growth.
激酶實(shí)驗(yàn)	HEK-GPR119 cells are transfected with GloSensor 22F plasmid and used for dynamic cAMP measurements 24-30 h later. Cell suspensions are made by dislodging the cells using PBS wash and Accutase treatment followed by resuspension in culture media. Cells are then washed twice by pelleting through centrifugation (300 g, 5 min) and resuspension in assay buffer (Hank's Balanced Salt Solution supplemented with 20 mM HEPES and 0.01% fatty acid free BSA, pH 7.4). Cells are then counted and diluted to 600,000 cells/mL in buffer, before GloSensor cAMP reagent is added (2% v/v) and equilibrated with the cells for 2 h at 20°C with periodic mixing. 50 μl/well of cells are added to white-bottomed 384 well plates (30,000 cells/well) in triplicate and baseline luminescence is measuring using an Envision plate-reader. 5 μL of MBX-2982 (serially diluted in DMSO and then diluted 1:100 in assay buffer to obtain ×10 concentrated solution) is manually added to the assay wells to achieve the stated final concentration. Plates are incubated at 20°C with luminescence read at regular intervals to detect dynamic cAMP changes over time within the same wells. cAMP responses at each time-point are expressed as fold over control (vehicle-treated cells)[1].
體外活性	Micafungin (10 mg/mL) 在大多數(shù)分離株中從表型上減少了生物膜的形成。在micafungin處理的樣品中，所有測(cè)試的基因的mRNA轉(zhuǎn)錄水平也顯著降低[1]。Micafungin與KB425796-C的組合具有殺真菌作用，并顯著減少了CFU數(shù)量，與單獨(dú)使用每種化合物時(shí)在所有檢查的時(shí)間點(diǎn)觀察到的抑真菌作用（CFU無(wú)減少）形成鮮明對(duì)比[2]。
體內(nèi)活性	Micafungin (1 mg/kg) 與生理鹽水處理的小鼠相比，顯著延長(zhǎng)存活時(shí)間。與僅使用micafungin (0.1 mg/kg) 處理的小鼠相比，聯(lián)合使用micafungin (0.1 mg/kg)與KB425796-C (32 mg/kg) 的小鼠顯示出存活時(shí)間有延長(zhǎng)的趨勢(shì)。micafungin處理的小鼠肝臟中CFU數(shù)量減少，盡管其清除效果不如在腎臟中觀察到的那樣顯著。micafungin與KB425796-C的聯(lián)合治療與僅使用micafungin治療相比，在所有檢測(cè)的劑量下都顯著減少了CFU數(shù)量。與AMPH治療的動(dòng)物相比，KB425796-C聯(lián)合micafungin的清除效果更為顯著[2]。
存儲(chǔ)條件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (34.82 mM) H2O : 100 mg/mL (77.38 mM)
關(guān)鍵字	Inhibitor \| Antibiotic \| Fungal \| inhibit \| Micafungin \| FK463 \| FK-463 \| Micafungin sodium
相關(guān)產(chǎn)品	Cefaclor monohydrate \| Potassium gluconate \| Dehydroacetic acid sodium \| G-418 disulfate \| Doxycycline \| Neomycin sulfate \| Geraniol \| Metronidazole \| EDTA copper(II) disodium salt \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate
相關(guān)庫(kù)	經(jīng)典已知活性庫(kù) \| 抗真菌庫(kù) \| 已知活性化合物庫(kù) \| FDA 上市藥物庫(kù) \| 臨床期小分子藥物庫(kù) \| 藥物功能重定位化合物庫(kù)

關(guān)鍵字：米卡芬凈鈉|||Mycamine Sodium|||FK463 Sodium|||FK 463|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專(zhuān)業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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