中文名稱:鹽酸阿替卡因 | 英文名稱:Articaine hydrochloride |
CAS:23964-57-0 | 品牌: TargetMol |
產(chǎn)地: 美國 | 保存條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
純度規(guī)格: 99.88% | 產(chǎn)品類別: 抑制劑 |
貨號: T2131 |
名稱 | Articaine hydrochloride |
描述 | Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. |
體內(nèi)活性 | The time to maximum drug concentrations of articaine occurs about 10 to 15 minutes after submucosal injection of articaine 4% 80 mg. The elimination half-time of articaine is about 20 minutes. Articaine is better able to diffuse through soft tissue and bone than other local anaesthetics, the concentration of articaine in the alveolus of a tooth in the upper jaw after extraction is about 100 times higher than that in systemic circulation. [1] Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient. [2] Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. [3] Articaine (4%) results in the success rate of 24% for the inferior alveolar nerve block in randomized, double-blind study. [4] Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution. [5] |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 60 mg/mL (187.01 mM) H2O : 59 mg/mL (183.9 mM) Ethanol : 60 mg/mL (187 mM) |
關(guān)鍵字 | dental | Articaine | Articaine Hydrochloride | NOD-like Receptor (NLR) | Hoe 045 | amide | pain relief | Hoe045 | Sodium Channel | inhibit | Na channels | kidney injury | Nuclear factor-κB | LPS | NF-κB | Na+ channels | Articaine hydrochloride | Nuclear factor-kappaB | Inhibitor |
相關(guān)產(chǎn)品 | Lidocaine hydrochloride | Benzocaine | Valproic Acid | Lidocaine | Mebeverine hydrochloride | Safinamide | Procaine | Amitriptyline hydrochloride | L-Aspartic aicd sodium | Lidocaine Hydrochloride hydrate | Riluzole | Phenytoin sodium |
相關(guān)庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 | 膜蛋白靶向化合物庫 | 藥物功能重定位化合物庫 | 疼痛相關(guān)化合物庫 | 抗癌臨床化合物庫 | 抗癌藥物庫 |
成立日期 | 2013-04-18 (12年) | 注冊資本 | 566.2651萬人民幣 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 化學(xué)試劑,生物活性小分子 | 經(jīng)營模式 | 貿(mào)易,試劑,定制,服務(wù) |
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