丹參酮IIA|T2906

價(jià)格	￥110
包裝	20mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱(chēng):丹參酮IIA	英文名稱(chēng):Tanshinone IIA
CAS:568-72-9	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| Shipping with blue ice.
純度規(guī)格: 99.54%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T2906

Product Introduction

Bioactivity

名稱(chēng)	Tanshinone IIA
描述	Tanshinone IIA (Tanshinone B) is a diterpene quinone natural product that targets the protein kinase domain of VEGF/VEGFR2. Tanshinone IIA inhibits angiogenesis and exhibits anti-inflammatory, antioxidant, and therapeutic activities against coronary heart disease.
細(xì)胞實(shí)驗(yàn)	Tanshinone IIA (Tan IIA) is dissolved in DMSO (10 mM) and stored (in dark and -20°C), and serially diluted in a RPMI 1640 medium immediately prior to experiments[1]. A549 cells are counted in logarithmic phase and 6000 cells (90 μL volume) are placed in 96-well plates. 10 μL varying concentrations of Tanshinone IIA (final concentrations 80, 60, 40, 30, 20, 15, 10, 5 and 2.5 μM) and ADM (final concentrations 8, 4, 2, 1, 0.5 and 0.25 μM) are added into drug groups, while negative control group (vehicle group) is only added 10 μL DMSO or normal saline without Tanshinone IIA or ADM. Cells are incubated for an additional 2 h with CCK-8 reagent (100 μL/mL medium) and the absorbance is read at 450 nm using a microplate reader. Cell proliferation inhibition rates are calculated according to the following formula: the proliferation inhibition ratio (%)=1-[(A1-A4)/(A2-A3)]×100, where, A1 is the OD value of drug experimental group, A2 is the OD value of blank control group, A3 is the OD value of the RPMI1640 medium without cells, and A4 is the OD value of drugs with the same concentration as A1 but without cells. The IC50 value, which represents the concentration of the drug that demonstrates 50% of cell growth inhibition, is calculated by nonlinear regression analysis using GraphPad Prism software[1].
體外活性	方法: 人乳腺癌細(xì)胞 MCF-7 用 Tanshinone IIA (0.0625-1 μg/mL) 處理 5 天，使用 MTT assay 檢測(cè)細(xì)胞活力。結(jié)果: Tanshinone IIA 對(duì)細(xì)胞生長(zhǎng)有劑量和時(shí)間依賴性的抑制作用，IC50 為 0.25 μg/mL，1 μg/mL 時(shí)最大抑制細(xì)胞生長(zhǎng) (>80%)。[1] 方法: 人乳腺癌細(xì)胞 MCF-7 用 Tanshinone IIA (5-20 μM) 處理 12-48 h，使使用 Flow cytometry 檢測(cè)細(xì)胞凋亡。結(jié)果: 在 Tanshinone IIA 的存在下觀察到濃度依賴性的細(xì)胞凋亡誘導(dǎo)。[2]
體內(nèi)活性	方法: 為檢測(cè)體內(nèi)抗腫瘤活性，將 Tanshinone IIA (30 mg/kg) 注射給攜帶 MCF-7 腫瘤異種移植物的 BALB/c-nu 裸鼠，每周五次，持續(xù)兩周。結(jié)果: Tanshinone IIA 治療顯著減少了腫瘤的大小和重量。Tanshinone IIA 處理增強(qiáng)了體內(nèi) PARP 和 caspase-3 的切割。[2]
存儲(chǔ)條件	Powder: -20°C for 3 years \| Shipping with blue ice.
溶解度	DMSO : 2.94 mg/mL (10 mM), The compound is unstable in solution. Please use soon. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 0.29 mg/mL (0.99 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
關(guān)鍵字	inhibit \| VEGFR \| Vascular endothelial growth factor receptor \| Tanshinone IIA \| Inhibitor
相關(guān)產(chǎn)品	Ribociclib \| Lenvatinib \| Axitinib \| Sorafenib tosylate \| Lenvatinib mesylate \| Sanguinarine chloride \| Regorafenib \| Pazopanib \| Nintedanib \| Sorafenib \| Regorafenib monohydrate \| Taxifolin

關(guān)鍵字：丹參酮IIA|||Tanshinone B|||Dan Shen ketone|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專(zhuān)業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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