醋酸奧曲肽|T4119

價(jià)格	￥242	￥413	￥618
包裝	5mg	10mg	25mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-09-14

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產(chǎn)品詳情

中文名稱:醋酸奧曲肽	英文名稱:Octreotide Acetate
CAS:79517-01-4	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.87%	產(chǎn)品類別: 抑制劑
貨號(hào): T4119

Product Introduction

Bioactivity

名稱	Octreotide Acetate
描述	Octreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
動(dòng)物實(shí)驗(yàn)	Octreotide (acetate) is formulated in saline.MiceThirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq. RatTwelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at ?20°C until analysis.
體內(nèi)活性	Octreotide處理組與鹽水組相比，腫瘤體積顯著減少。Octreotide-PPSG（1.4 mg/kg，i.p.）的抗腫瘤效果超過(guò)Octreotide-soln（100 μg/kg，i.p.）。Octreotide處理在原發(fā)性HCC攜帶大鼠中顯著抑制SSTR2和SSTR5的表達(dá)水平，與鹽水組相比。Octreotide-PPSG對(duì)SSTR2和SSTR5的表達(dá)抑制作用大于Octreotide-soln處理組。 Octreotide Acetate 鹽試驗(yàn)劑量在2小時(shí)內(nèi)將血清胃泌素水平顯著降低至基線的約三分之一，效果持續(xù)約6小時(shí)。第21天，開(kāi)始使用持續(xù)釋放配方的 Octreotide Acetate 鹽（5 mg肌內(nèi)注射，每4周一次）。
存儲(chǔ)條件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 29 mg/mL
關(guān)鍵字	inhibit \| Octreotide \| SMS-201995 \| SMS201995 \| Inhibitor \| SSTR \| Somatostatin Receptor \| SSTRs \| Octreotide Acetate \| SMS 201-995
相關(guān)產(chǎn)品	Cyclosomatostatin Acetate \| BIM-23190 aceate \| CYN 154806 TFA \| FK962 \| 2-Aminoethanethiol \| Somatostatin acetate \| (1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid \| Cortistatin 14, human, rat acetate \| L-796,778 \| L-803087
相關(guān)庫(kù)	環(huán)肽庫(kù) \| JAK-STAT 化合物庫(kù) \| 多肽分子庫(kù) \| 臨床前化合物庫(kù) \| NO PAINS 化合物庫(kù) \| 大環(huán)化合物庫(kù)

關(guān)鍵字：醋酸奧曲肽|||SMS 201995|||Longastatin|||Sandostatin|||SMS 201-995 (acetate)|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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