阿尼芬凈|T6088

價(jià)格	￥233	￥323	￥519
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:阿尼芬凈	英文名稱:Anidulafungin
CAS:166663-25-8	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.15%	產(chǎn)品類別: 抑制劑
貨號(hào): T6088

Product Introduction

Bioactivity

名稱	Anidulafungin
描述	Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.
細(xì)胞實(shí)驗(yàn)	Anidulafungin is dissolved in DMSO and stored, and then diluted[2]. Stocks of CD101 (formerly SP 3025, biafungin, AF-025) are prepared fresh in 100% DMSO prior to use. The comparator antifungals Anidulafungin (ANF), Caspofungin (CSF), and Amphotericin B (AMB) are also prepared in 100% DMSO. MIC assays are performed via broth microdilution in accordance with CLSI guidelines, with the exception that test compounds are made up at a 50× final assay concentration and 100 μL assay mixture volumes are used (2 μL added to 98 μL of broth containing cells at 0.5×103 to 2.5×103 CFU/mL). All MIC assays are run at least three times, and a representative data set is shown. Quality control (QC) is assessed throughout the study via comparison of MIC values derived for WT C. krusei strain ATCC 6258 for AMB, CSF, and ANF with previously reported CLSI 24-h broth microdilution QC ranges[2].
激酶實(shí)驗(yàn)	FITC-S1P quantification/Caliper assay: A 384-well format of the SphK enzyme assay based on separation of FITC-S1P from unreacted FITC-sphingosine substrate using a microfluidic capillary electrophoresis mobility-shift system is developed. Briefly, 3 nM SphK1–His6 is incubated with 1 μM FITC-sphingosine, 20 μM ATP and 10 μM compound (a final concentration of DMSO of 2 %) in a buffer containing 100 mM Hepes (pH 7.4), 1 mM MgCl2,0.01% Triton X-100, 10% glycerol, 100 μM sodium orthovanadate and 1 mM DTT for 1 h in a 384-well Matrical MP-101-1-PP plate. Reaction mixtures (10 μL) are quenched by the addition of 20 μL of 30 mM EDTA and 0.15% Coating Reagent-3 in 100 mM Hepes, and a small aliquot of each reaction (a few nanolitres) is analysed in the Caliper LabChip 3000 instrument under -1.5 psi (psi=6.9 kPa) pressure, a downstream voltage of -1900 V and a sip time of 0.2 s. Phosphorylated fluorescent product and unphosphorylated fluorescent substrate appeared as distinctive peaks and are quantified using the Caliper data.
體外活性	Anidulafungin（LY-303366）對(duì)所有測(cè)試的Candida albicans（n=99）、Candida glabrata（n=18）、Candida tropicalis（n=10）分離株的最低抑菌濃度（MIC）均≤0.32 μg/mL。Anidulafungin對(duì)Aspergillus種（90%分離株被抑制的最低有效濃度，0.02 μg/mL）亦有活性（n=20），但對(duì)Candida parapsilosis的活性較低（90%分離株被抑制的MIC [MIC90]，5.12 μg/mL）（n=10），對(duì)C. neoformans（MIC90 >10.24 μg/mL）（n=15）和B. dermatitidis（MIC90，16 μg/mL）（n=29）無(wú)活性。Fluconazole對(duì)三株C. tropicalis、七株C. glabrata和兩株Candida krusei的MIC均≥16 μg/mL。對(duì)這12株中的11株，Anidulafungin的MIC范圍從0.08至0.32 mg/mL。第十二株為C. krusei（Fluconazole MIC，32 μg/mL)，其Anidulafungin MIC為1.28 mg/mL。這12株的90%抑制MIC（MIC90）為0.32 μg/mL。對(duì)于Fluconazole MIC≥8 μg/mL的其余18株C. glabrata和C. tropicalis分離株，Anidulafungin的MIC90也是0.32 mg/mL。Anidulafungin對(duì)Fluconazole MIC ≥16 mg/mL的Candida種同對(duì)Fluconazole MIC ≥8 μg/mL的種表現(xiàn)出同等活性。與C. albicans、C. glabrata和C. tropicalis相比，Anidulafungin對(duì)C. neoformans和B. dermatitidis的活性顯著較低。Ketoconazole和amphotericin B是對(duì)C. neoformans和B. dermatitidis測(cè)試中最活躍的抗真菌藥。Anidulafungin對(duì)Aspergillus種展示出強(qiáng)大的體外活性，其MEC90為0.02 μg/mL。對(duì)照種酵母分離株的Anidulafungin MIC為C. albicans ATCC 90028的0.02 μg/mL，C. glabrata ATCC 90030的0.16 mg/mL，C. neoformans ATCC 90112的>10.24 μg/mL。通過(guò)CD101選擇的菌株若CD101 MIC增加至少2倍，其Anidulafungin（ANF）和/或Caspofungin（CSF）的MIC也至少增加2倍。
存儲(chǔ)條件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 93 mg/mL (81.6 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
關(guān)鍵字	LY-303366 \| LY 303366 \| Inhibitor \| inhibit \| Fungal \| Antibiotic \| Anidulafungin
相關(guān)產(chǎn)品	Cefaclor monohydrate \| Potassium gluconate \| Dehydroacetic acid sodium \| G-418 disulfate \| Doxycycline \| Neomycin sulfate \| Geraniol \| Metronidazole \| EDTA copper(II) disodium salt \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate
相關(guān)庫(kù)	微生物天然產(chǎn)物庫(kù) \| 抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 已知活性化合物庫(kù) \| 抗真菌庫(kù) \| 抗生素庫(kù) \| 上市藥物庫(kù) \| FDA 上市藥物庫(kù) \| 大環(huán)化合物庫(kù) \| 免疫/炎癥分子化合物庫(kù) \| 藥物功能重定位化合物庫(kù) \| 兒童藥物庫(kù)

關(guān)鍵字：阿尼芬凈|||LY303366|||Eraxis|||Ecalta|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

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VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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