卡泊三醇一水合物|TQ0244

價(jià)格	￥233	￥523	￥778
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:卡泊三醇一水合物	英文名稱:Calcipotriol monohydrate
CAS:147657-22-5	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.57%	產(chǎn)品類別: 抑制劑
貨號(hào): TQ0244

Product Introduction

Bioactivity

Name	Calcipotriol monohydrate
Description	Calcipotriol monohydrate is an analog of Vitamin D3 with a high affinity for the vitamin D receptor. Calcipotriol monohydrate can be used for studies about psoriasis.
Cell Research	Normal human epidermal keratinocytes are grown in serum-free keratinocyte growth medium Epilife and used at the third passage in all experiments. The growth supplement is omitted 48 h before experiments. As a control, IL-17A and IL-22 are either added or not added to the cells. Cultured NHEK cells are stimulated with IL-17A (200 ng/mL) and/or IL-22 (200 ng/mL) followed by co-incubation in the presence or absence of Calcipotriol at 0.2-40 nM to test its modulatory effect. Cells are harvested 3 days later and subjected to real-time qPCR. Culture supernatants are also collected and frozen at -80°C until used for ELISA [1].
Animal Research	The 160 female SKH-1 hairless mice (6-7 weeks of age) are used. After UV treatment, mice without tumors are randomly divided into five groups, four chemoprevention groups (Diclofenac plus DFMO; Diclofenac plus Calcipotriol; DFMO plus calcitriol; and Diclofenac plus DFMO plus Calcipotriol) and one placebo group (skin lotion). The mice are treated with test mixtures once a day, five days a week, for a total of 17 weeks. The test mixtures are applied topically on the dorsal surface of the mice. Ten microliters are applied by a pipette after which the mixture is rubbed onto the skin. This corresponded to the following doses of each active substance in the treatments: 100 μg/week for Diclofenac (30 mg/g undiluted), 0.166 μg/week for Calcitriol (50 μg/g undiluted), and 463.3 μg/week for DFMO (139 mg/g undiluted) [3].
In vitro	Calcipotriol monohydrate（100, 10, 和 1 ng/mL）顯著提升了NK細(xì)胞表面NKp30的表達(dá)量，在4小時(shí)的孵育后[1]。當(dāng)NHEK細(xì)胞未被IL-17A或IL-22刺激時(shí)，Calcipotriol monohydrate輕微增強(qiáng)（0.2 nM）IL-8 mRNA表達(dá)，或無(wú)影響（2-20 nM）。加入IL-17A和IL-22后，IL-8的mRNA表達(dá)顯著提升，證實(shí)了我們之前的研究。這種IL-8 mRNA表達(dá)的增強(qiáng)，通過(guò)Calcipotriol monohydrate（2, 20 和 40 nM）以劑量依賴方式被抑制[2]。
In vivo	在經(jīng)過(guò)Diclofenac加Calcipotriol monohydrate（p=0.018）和Diclofenac加DFMO加Calcipotriol monohydrate（p=0.002）處理的組別中，與安慰劑（線性回歸模型）[3]相比，體重增加顯著較小。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 95 mg/mL (220.61 mM), Sonication is recommended. DMSO : 95 mg/mL (220.61 mM), Sonication is recommended.
Keywords	VD/VDR \| Vitamin D receptor \| Calcipotriol \| Vitamin D \| Calcipotriol monohydrate \| Calcipotriol Monohydrate \| inhibit \| Inhibitor
Inhibitors Related	Retinyl acetate \| Ercalcitriol \| Ercalcidiol \| 24, 25-Dihydroxy VD2 \| (24S)-24,25-Dihydroxyvitamin D3 \| DL-Panthenol \| Maxacalcitol \| Biotin \| 5,6-trans-Vitamin D3 \| Impurity C of Calcitriol \| Calcipotriol \| Acenocoumarol

關(guān)鍵字：卡泊三醇一水合物|||鈣泊三醇一水合物|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

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公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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