Human IL-6 R alpha / CD126 Protein, Fc Tag

分子別名（Synonym）

IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IL-6 R alpha, Fc Tag (ILR-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 365 (Accession # P08887-1).

Predicted N-terminus: Leu 20

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 65.0 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白細(xì)胞介素6受體（IL6R）也稱為CD126（分化簇126），是一種強(qiáng)效的多效性細(xì)胞因子，調(diào)節(jié)各種組織的細(xì)胞生長和分化，尤其因其在免疫反應(yīng)和急性期反應(yīng)中的作用而聞名。IL6R是由IL-6受體亞基（IL6R）和白細(xì)胞介素6信號(hào)轉(zhuǎn)導(dǎo)子糖蛋白130組成的蛋白質(zhì)復(fù)合物。IL6R也表示編碼該亞基的人類基因。有報(bào)道稱，編碼不同異構(gòu)體的剪接轉(zhuǎn)錄變體。IL6R亞基也被許多其他細(xì)胞因子共享。IL6R的可溶性形式來源于膜結(jié)合IL6Rα的蛋白水解切割，并通過使IL6配體可與信號(hào)轉(zhuǎn)導(dǎo)子gp130接觸而起激動(dòng)作用。IL6和IL6R的失調(diào)產(chǎn)生與多種炎性疾病和惡性腫瘤的發(fā)病機(jī)制有關(guān)，如多發(fā)性骨髓瘤、類風(fēng)濕性關(guān)節(jié)炎或骨質(zhì)疏松癥，據(jù)報(bào)道，人源化抗IL6R單克隆抗體是一種有前景的藥物，適用于IL6驅(qū)動(dòng)的疾病的治療方法。白細(xì)胞介素-6受體已被證明與白細(xì)胞介蛋白-6和睫狀神經(jīng)營養(yǎng)因子相互作用。