Human Annexin A5 Protein, Tag Free
分子別名(Synonym)
ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5
表達區(qū)間及表達系統(tǒng)(Source)
Human ANXA5, Tag Free (AN5-H5118) is expressed from E. coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1).
Predicted N-terminus: Met 1
蛋白結構(Molecular Characterization)
This protein carries no "tag".
The protein has a calculated MW of 35.9 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>98% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
Annexin A5是一種磷脂結合蛋白,在鈣的存在下以高親和力和選擇性結合PS。PS主要位于面向細胞質的膜小葉中。然而,最近的研究結果表明,每種細胞類型都有在其細胞表面暴露PS的分子機制。這種機制在細胞凋亡過程中被激活。一旦PS暴露在細胞表面,它就會表現(xiàn)出促凝和促炎活性。Annexin A5會與PS暴露的凋亡細胞結合,并能抑制垂死細胞的促凝和促炎活性。Annexin A5也被確定為凝血級聯(lián)中的一種抗凝蛋白,作為凝血酶原激活的抑制劑。Annexin A5抗體的存在與系統(tǒng)性紅斑狼瘡(SLE)、復發(fā)性自然流產(chǎn)和系統(tǒng)性硬化癥(SSc)有關。
關鍵字: Annexin A5;Annexin A5蛋白;ANXA5重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。