Human B7-H6 / NCR3LG1 Protein, His Tag
分子別名(Synonym)
B7-H6,NCR3LG1,B7 Homolog 6
表達區(qū)間及表達系統(tǒng)(Source)
Human B7-H6 Protein, His Tag (B76-H52H8) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 262 (Accession # Q68D85-1).
Predicted N-terminus: Asp 25
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
B7基因家族在調(diào)節(jié)適應性免疫系統(tǒng)中至關重要。其中之一是最近發(fā)現(xiàn)的B7H6。人類和大鼠只有一個B7H6基因;然而,在爪蟾基因組中的單個大簇中檢測到許多B7H6基因。
嵌合抗原受體(CAR)T細胞療法在臨床試驗中已被證明對B細胞白血病具有持久和潛在的療效。在這項研究中,靶向NK細胞激活受體NKp30的配體B7H6,以創(chuàng)建靶向多種腫瘤類型的CAR。B7H6在各種原發(fā)性人類腫瘤上表達,包括白血病、淋巴瘤和胃腸道間質(zhì)瘤,但在正常組織上不是組成型表達的。
關鍵字: B7-H6;B7-H6蛋白;B7-H6重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。