Human CLEC4C / BDCA2 Protein, His Tag
分子別名(Synonym)
DLEC,CLEC4C,BDCA-2,CD303,CLECSF11,CLECSF7, HECL
表達區(qū)間及表達系統(tǒng)(Source)
Human CLEC4C, His Tag (CLC-H5245) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).
Predicted N-terminus: His
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 26.6 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
CLEC4C(C型凝集素結(jié)構(gòu)域家族4成員C),也稱為BDCA2、CLECSF11、CLECSF7、DLEC和CD303。凝集素型細胞表面受體,可能在樹突狀細胞捕獲抗原中發(fā)揮作用。特異性識別含有三糖表位Gal(β1-3/4)GlcNAc(β1-2)Man的非唾液酸化半乳糖封端的雙十元聚糖。與血清IgG結(jié)合。有效地將配體靶向抗原處理室和肽裝載室,以呈遞給T細胞??赡芙閷?dǎo)對漿細胞樣樹突狀細胞中IFN-α/β表達誘導(dǎo)的有效抑制??赡茏鳛樾盘柺荏w激活蛋白酪氨酸激酶并動員細胞內(nèi)鈣。
關(guān)鍵字: CLEC4C;CLEC4C蛋白;BDCA2重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。