Human Cadherin-17 / CDH17 Protein, His Tag
分子別名（Synonym）
Cadherin-17,CDH17,HPT-1,LI-cadherin
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Human Cadherin-17, His Tag (CA7-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Met 787 (Accession # Q12864).
Predicted N-terminus: Gln 23
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 86.9 kDa. The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150mM NaCl, pH8.0 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
Cadherin-17，也稱為肝腸鈣粘蛋白，屬于鈣依賴性細(xì)胞粘附分子鈣粘蛋白家族。體內(nèi)研究表明，CDH17敲除通過(guò)激活半胱氨酸天冬氨酸蛋白酶-3活性導(dǎo)致凋亡性PC腫瘤死亡。綜上所述，CDH17通過(guò)調(diào)節(jié)腫瘤凋亡信號(hào)通路作為對(duì)PC生長(zhǎng)至關(guān)重要的致癌分子發(fā)揮作用，并且CDH17可以作為開發(fā)抗PC治療方法的靶點(diǎn)。
關(guān)鍵字： Cadherin-17;Cadherin-17蛋白;CDH17重組蛋白;ACRO;百普賽斯;
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