Human Fc gamma RI / CD64 Protein, His Tag (SPR & BLI & MALS verified)
分子別名(Synonym)
FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI
表達區(qū)間及表達系統(tǒng)(Source)
Human CD64, His Tag (FCA-H52H1) is expressed from human 293 cells (HEK293). It contains AA Gln 16 - Leu 281 (Accession # P12314-1).
Predicted N-terminus: Gln 16
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 31.8 kDa. The protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
背景(Background)
識別IgG Fc部分的受體分為三組,分別稱為Fcγ-RI、RII和RIII,也分別稱為CD64、CD32和CD16。Fc-gamma RI以高親和力結(jié)合IgG,并在早期免疫反應中發(fā)揮作用。Fc-gamma RII和RIII是低親和力受體,在晚期免疫應答期間將IgG識別為多價抗原周圍的聚集體。
高親和力免疫球蛋白γ-Fc受體I也稱為FCGR1A、FCG1、FCGR1、CD64和IGFR1,是一種以高親和力結(jié)合單體IgG型抗體的完整膜糖蛋白,屬于免疫球蛋白超家族或FCGR1家族。FCGR1A/CD64含有3個Ig樣C2型(免疫球蛋白樣)結(jié)構(gòu)域。CD64僅在巨噬細胞和單核細胞上存在,但用IFNγ和G-CSF等細胞因子處理多形核白細胞可以誘導CD64在這些細胞上表達。
關鍵字: CD64;CD64蛋白;FCGR1A重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。