Human TGF-Beta 1 / TGFB1 Protein, Tag Free
分子別名(Synonym)
CEDLAP,TGF-beta 1,TGFB1,DPD1,TGF-beta-1,TGFB
表達區(qū)間及表達系統(tǒng)(Source)
Human TGF-Beta 1 Protein, Tag Free (TG1-H4212) is expressed from human 293 cells (HEK293). It contains AA Ala 279 - Ser 390 (Accession # P01137-1).
Predicted N-terminus: Ala 279
蛋白結構(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 12.8 kDa (monomer). The protein migrates as 14 kDa (monomer) under reducing (R) condition, and 25 kDa (Dimer) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).
內毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
宿主蛋白殘留(Host Cell Protein)
<0.5 ng/μg of protein tested by ELISA.
宿主核酸殘留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
無菌(Sterility)
Negative
支原體(Mycoplasma)
Negative.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 0.085% TFA in 30% ACN with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.


背景(Background)
轉化生長因子β1(TGFB1)也稱為TGF-β1,CED,DPD1,TGFB。是細胞因子轉化生長因子β超家族的多肽成員。它是一種分泌蛋白,具有許多細胞功能,包括控制細胞生長,細胞增殖,細胞分化和凋亡。TGFB1蛋白有助于控制細胞的生長和分裂(增殖),細胞成熟以執(zhí)行特定功能(分化),細胞運動(運動)和細胞自我破壞(凋亡)的過程。TGFB1蛋白遍布全身,在出生前的發(fā)育,血管的形成,肌肉組織和體脂發(fā)育的調節(jié),傷口愈合和免疫系統(tǒng)功能中起作用。TGFB1在構成骨骼的組織中特別豐富,它有助于調節(jié)骨骼的生長,并且在細胞之間的空間(細胞外基質)中形成復雜的晶格。在細胞內,這種蛋白質被關閉(無活性),直到它接收到化學信號變得活躍。TGFB1在控制免疫系統(tǒng)中起著重要作用,并且在不同類型的細胞或處于不同發(fā)育階段的細胞上顯示出不同的活性。大多數(shù)免疫細胞(或白細胞)分泌TGFB1。已顯示TGFB1與TGFβ受體1,LTBP1,YWHAE,EIF3I和核心蛋白聚糖相互作用。
關鍵字: TGF-Beta 1;TGF-Beta 1蛋白;TGF-Beta 1重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。