ADORA2A產(chǎn)品信息
英文名稱:Adenosine A2a receptor
中文名稱:腺苷A2a受體
靶點(diǎn)別稱:ADORA2A
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
This product is not suitable for cell based experiments due to cytotoxicity of DDM.
DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.
DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
運(yùn)輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
ADORA2A分子背景
該基因編碼鳥嘌呤核苷酸結(jié)合蛋白(G蛋白)偶聯(lián)受體(GPCR)超家族的成員,該超家族又分為類別和亞型。受體是七通道跨膜蛋白,對細(xì)胞外信號作出反應(yīng)并激活細(xì)胞內(nèi)信號轉(zhuǎn)導(dǎo)通路。這種蛋白是A2A亞型的腺苷受體,它使用腺苷作為首選的內(nèi)源性激動劑,并優(yōu)先與G(s)和G(olf)家族的G蛋白相互作用,以增加細(xì)胞內(nèi)cAMP水平。它在許多生物功能中起著重要作用,如心律和循環(huán)、腦和腎血流、免疫功能、疼痛調(diào)節(jié)和睡眠。它與炎癥性疾病和神經(jīng)退行性疾病等病理生理?xiàng)l件有關(guān)。選擇性剪接導(dǎo)致多種轉(zhuǎn)錄變體。已經(jīng)鑒定出一種由上游SPECC1L(具有calponin同源性和卷曲螺旋結(jié)構(gòu)域1-like的精子抗原)和ADORA2A(腺苷A2a受體)基因序列組成的通讀轉(zhuǎn)錄本,但人們認(rèn)為它是非編碼的。
關(guān)鍵字: ADORA2A;ADORA2A蛋白;腺苷A2a受體;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。