IGFBP3產(chǎn)品信息
英文名稱:Insulin-like growth factor binding protein III
中文名稱:胰島素樣生長因子結(jié)合蛋白-III
靶點別稱:IGFBP3,BP-53,IBP3
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
IGFBP3分子背景
胰島素樣生長因子結(jié)合蛋白3也稱為IGFBP3,是一種在人類中由IGFBP3基因編碼的蛋白質(zhì)。IGFBP3與IGF1或IGF2以及糖蛋白胰島素樣生長因子酸不穩(wěn)定亞基(ALS)形成約140~150 kDa的三元復(fù)合物,從而改變IGFs與其細(xì)胞表面受體的相互作用。IGFBP3根據(jù)細(xì)胞環(huán)境發(fā)揮促凋亡或生長刺激作用。研究表明,IGFBP3可以誘導(dǎo)依賴或獨立于IGF-IGF受體軸的凋亡,因此在某些癌癥中充當(dāng)腫瘤發(fā)生和進(jìn)展的負(fù)調(diào)節(jié)因子。在肝臟的非分支細(xì)胞中發(fā)現(xiàn)了最高的表達(dá)水平。表達(dá)水平在子宮外生活期間也較高,在青春期達(dá)到峰值。
關(guān)鍵字: IGFBP3;IGFBP3蛋白;IGFBP3重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。