CXCL13產(chǎn)品信息

英文名稱：C-X-C motif chemokine 13

中文名稱：C-C基序趨化因子-13

靶點(diǎn)別稱：CXCL13,BCA-1

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CXCL13分子背景

CXCL13最初被稱為BLC（B淋巴細(xì)胞趨化因子）或BCA-1（B細(xì)胞吸引趨化因子1），是一種穩(wěn)態(tài)趨化因子。它由次級(jí)淋巴組織（卵泡）B細(xì)胞區(qū)域的基質(zhì)細(xì)胞組成性分泌，如脾臟、淋巴結(jié)、扁桃體和派爾氏結(jié)。CXCL13在協(xié)調(diào)次級(jí)淋巴器官空間不同區(qū)域內(nèi)的細(xì)胞遷移中起著關(guān)鍵作用。它強(qiáng)烈吸引B淋巴細(xì)胞，同時(shí)只促進(jìn)少量T細(xì)胞和巨噬細(xì)胞的遷移。CXCL13通過(guò)其受體CXCR5發(fā)揮其功能，該受體最初是從伯基特淋巴瘤中分離出來(lái)的，因此被命名為伯基特淋巴瘤受體1（BLR1）。