FGF R2 (IIIc)產(chǎn)品信息

英文名稱：Fibroblast growth factor receptor 2

中文名稱：成纖維細胞生長因子受體-2

靶點別稱：FGF R2 (IIIc),FGFR2B,FGFR2

物種：Human

屬性：Protein

標記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

FGF R2 (IIIc)分子背景

酪氨酸蛋白激酶作為成纖維細胞生長因子的細胞表面受體，在細胞增殖、分化、遷移和凋亡的調(diào)節(jié)以及胚胎發(fā)育的調(diào)節(jié)中起著至關重要的作用。正常胚胎模式、滋養(yǎng)層功能、肢芽發(fā)育、肺形態(tài)發(fā)生、成骨和皮膚發(fā)育所需。在成骨細胞分化、增殖和凋亡的調(diào)節(jié)中起著至關重要的作用，是正常骨骼發(fā)育所必需的。促進角質(zhì)形成細胞和未成熟成骨細胞的細胞增殖，但促進分化的成骨細胞凋亡。磷酸PLCG1、FRS2和PAK4。配體結合導致幾個信號級聯(lián)的激活。PLCG1的激活導致細胞信號分子二?；视秃图〈?/span>1,4,5-三磷酸的產(chǎn)生。FRS2的磷酸化觸發(fā)GRB2、GAB1、PIK3R1和SOS1的募集，并介導RAS、MAPK1/ERK2、MAPK3/ERK1和MAP激酶信號通路以及AKT1信號通路的激活。FGFR2信號傳導受到泛素化、內(nèi)化和降解的下調(diào)。導致組成型激酶激活或損害正常FGFR2成熟、內(nèi)化和降解的突變會導致異常信號傳導。過度表達的FGFR2促進STAT1的激活。