CRTAM產(chǎn)品信息

別稱：CRTAM,CD355

物種：Human/Cynomolgus

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CRTAM分子背景

I類限制性T細(xì)胞相關(guān)分子（CRTAM）是連接蛋白家族和免疫球蛋白超家族的成員，也被稱為細(xì)胞毒性和調(diào)節(jié)性T細(xì)胞分子，由活化的CD8+和NK T細(xì)胞表達(dá)。CRTAM存在于脾臟、胸腺、小腸、外周血中，令人驚訝的是，在大腦中，它被小腦的浦肯野細(xì)胞高度表達(dá)。CRTAM/IGSF4粘附的高親和力使CRTAM能夠破壞IGSF4的同型相互作用（3-5）。表達(dá)CRTAM的CD8+細(xì)胞與IGSF4和T細(xì)胞受體的共結(jié)合誘導(dǎo)IFN-γ或IL-22的產(chǎn)生增加（3，4）。此外，還提出了通過NK細(xì)胞介導(dǎo)的對表達(dá)IGSF4的腫瘤的排斥在癌癥監(jiān)測中的作用。