GSK2256294A是一種有效的, 可逆的的可溶性環(huán)氧化物水解酶(sEH)抑制劑, IC50值為27 pM。
GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH.
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