中文名：BG45
英文名：BG45
英文別名：BG45|926259-99-6|N-(2-aminophenyl)pyrazine-2-carboxamide|BG-45|N-(2-Aminophenyl)-2-pyrazinecarboxamide|12P6IK4ZUX|UNII-12P6IK4ZUX|2-Pyrazinecarboxamide, N-(2-aminophenyl)-|CHEMBL4283263|BG45, HDAC3 Inhibitor|SCHEMBL18064956|CHEBI:125522|LMWPVSNHKACEKW-UHF
純度：97%
貨號：B413814
包裝：10mg、200mg、50mg
Cas號：926259-99-6
存儲溫度：-20°C儲存
產(chǎn)品介紹：
Information
BG45 is a class IHDACinhibitor withIC50of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively.
Targets
HDAC3 ; HDAC1 ; HDAC2 289 nM; 2 μM; 2.2 μM
In vitro
BG45 causes significant cell growth inhibition and induces caspase-dependent apoptosis in a series of MM cells. In RPMI8226 cells, BG45 synergistically enhances bortezomib-induced cytotoxicity.
In vivo
In mice bearing MM.1S xenograft of human MM, BG45 (50 mg/kg, i.p.) significantly inhibits MM tumor growth. When in combination with bortezomib, BG45 (50 mg/kg, i.p.) enhances bortezomib-induced cytotoxicity.
Cell Research(from reference)
Cell lines：MM.1S, RPMI8226, U266, H929, MM.1\u2009R, RPMI-LR5, OPM1, OPM2 and RPMI-DOX40 cells?
Concentrations：~30 μM?
Incubation Time：48 h?
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關鍵字： BG45;926259-99-6;N-(2-aminophenyl)pyrazine-2-carboxamide;BG-45
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