MARCO產品信息
別稱:MARCO, SCARA2
物種:Human
屬性:Protein
標記:Biotin-labeled/Unconjugated
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
MARCO分子背景
MARCO也被稱為清道夫受體A類成員2和SCARA2。結合革蘭氏陽性和革蘭氏陰性細菌的模式識別受體(PRR)。也在肺泡巨噬細胞結合未經聲波處理的顆粒中發(fā)揮作用。與分泌球蛋白SCGB3A2結合。MARCO連接促進巨噬細胞產生炎癥介質。MARCO介導的一些配體的內化阻止了它們對細胞表面TLR4的激活,但使它們能夠激活細胞內TLR3。MARCO有助于清除凋亡細胞和吸入細菌、肥大細胞介導的矽肺,以及改善過敏原或臭氧誘導的肺部炎癥。它是脾邊緣區(qū)組織和脾巨噬細胞與B細胞相互作用所必需的。
關鍵字: MARCO;MARCO蛋白;SCARA2蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。