LAIR-1產(chǎn)品信息

英文名稱：Leukocyte-associated immunoglobulin-like receptor 1

中文名稱：白細(xì)胞相關(guān)免疫球蛋白樣受體-1

靶點別稱：LAIR1,CD305

物種：Human/Mouse/Rhesus macaque

屬性：Protein

標(biāo)記：Biotin-labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

LAIR-1用戶評價

LAIR-1分子背景

白細(xì)胞相關(guān)免疫球蛋白樣受體-1（LAIR-1）在大多數(shù)人外周血單核白細(xì)胞上組成型表達(dá)。LAIR-1或CD305是一種跨膜糖蛋白，具有單個免疫球蛋白樣結(jié)構(gòu)域和含有兩個基于酪氨酸的免疫受體抑制基序的細(xì)胞質(zhì)尾部。LAIR-1在激活后招募SHP-1和SHP-2磷酸酶，LAIR-1抗原在自然殺傷（NK）細(xì)胞上的交聯(lián)導(dǎo)致NK細(xì)胞介導(dǎo)的細(xì)胞毒性受到強(qiáng)烈抑制。

作為一種抑制性受體，對自然殺傷（NK）細(xì)胞、B細(xì)胞和T細(xì)胞的細(xì)胞溶解功能起組成性負(fù)調(diào)控作用。Tyr磷酸化的激活導(dǎo)致磷酸酶PTPN6和PTPN11的募集和激活。它還可以減少B細(xì)胞受體連接引起的細(xì)胞內(nèi)鈣的增加。與LAIR1相關(guān)的疾病包括慢性活動性EB病毒感染和復(fù)發(fā)性風(fēng)濕病。