E-Cadherin產(chǎn)品信息
英文名稱:Cadherin-1
中文名稱:鈣粘蛋白-1
靶點別稱:Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
無菌(Sterility)
The sterility testing was performed by membrane filtration method.
支原體(Mycoplasma)
Negative.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

E-Cadherin分子背景
Cadherins是鈣依賴性細胞粘附蛋白。它們在連接細胞時優(yōu)先以親同的方式與自己相互作用;鈣粘蛋白因此可能有助于異質(zhì)細胞類型的分選。鈣粘蛋白-1(CDH1)也稱為上皮鈣粘蛋白(E-Cadherin)、CD_抗原(CD324)、UVO ECAD和CDHE,CDH1/CD324包含5個鈣粘蛋白結(jié)構(gòu)域。CDH1/CD324/ECAD在非神經(jīng)上皮組織中表達。CDH1/E-CAD參與調(diào)節(jié)上皮細胞的細胞間粘附、遷移和增殖的機制,并具有強大的侵襲抑制作用。它是整合素α-E/β-7的配體。E-Cad促進Abeta前體的非淀粉樣降解,對APP C99和C83的產(chǎn)生具有很強的抑制作用。CDH1/CD324/ECAD缺陷是遺傳性彌漫性癌癥(HDGC)的病因。

關(guān)鍵字: E-Cadherin;鈣粘蛋白-1;Cadherin-1;E-Cadherin蛋白;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。