Flt-3產(chǎn)品信息

英文名稱：Tyrosine-protein kinase receptor FLT3

中文名稱：酪氨酸蛋白激酶受體FLT3

靶點別稱：Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

物種：Human/Mouse/Cynomolgus

屬性：Protein

標(biāo)記：Biotin-labeled/FITC Labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Flt-3用戶評價

Flt-3分子背景

Flt-3（受體型酪氨酸蛋白激酶FLT3）也被稱為FLK-2（胎兒肝激酶-2）、STK-1（干細(xì)胞酪氨酸激酶1）、CD135。FLT3是一種細(xì)胞因子受體，屬于受體酪氨酸激酶III類。酪氨酸蛋白激酶作為細(xì)胞因子FLT3LG的細(xì)胞表面受體，調(diào)節(jié)造血祖細(xì)胞和樹突狀細(xì)胞的分化、增殖和存活。促進(jìn)SHC1和AKT1的磷酸化，以及下游效應(yīng)子MTOR的激活。促進(jìn)RAS信號傳導(dǎo)的激活和下游激酶的磷酸化，包括MAPK1/ERK2和/或MAPK3/ERK1。引起組成型激酶活性的突變通過激活多種信號通路促進(jìn)細(xì)胞增殖和抗凋亡。