Product Name:DOTA-LM3
CAS No.:1192362-32-5
Synonyms:生長抑素受體(SSTR)拮抗劑多肽DOTA-LM3
Catalog No.:218P632
Brand:HongTide(上海鴻肽生物)
Description:DOTA-LM3是一種生長抑素受體 (SSTR) 拮抗劑多肽,序列中含有8個氨基酸。DOTA-LM3通常通過同位素標記,如177Lu-DOTA-LM3和68Ga-DOTA-LM3,進行體內(nèi)腫瘤示蹤。68Ga-DOTA-LM3顯示出有優(yōu)異的生物分布特性、高度的腫瘤攝取能力、穩(wěn)定的腫瘤內(nèi)保留及較低的安全風(fēng)險。而177Lu-DOTA-LM3則被用于研究DOTATOC陰性的肝轉(zhuǎn)移案例,針對胰腺NET和廣泛性的腫瘤血栓形成治療具有潛在應(yīng)用價值。
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist peptide with a sequence containing 8 amino acids. DOTA-LM3 is typically used for in vivo tumor tracing through isotope labeling, such as 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. 68Ga-DOTA-LM3 exhibits excellent biological distribution characteristics, high tumor uptake capacity, stable intratumoral retention, and lower safety risks. 177Lu-DOTA-LM3 was used to study DOTATOC negative liver metastasis cases, which has potential application value in the treatment of pancreatic NET and widespread tumor thrombosis.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DOTA-{p-Cl-Phe}-{D-Cys}-Y-{D-4-amino-Phe(carbamoyl)}-KTC-{D-Tyr}-NH2(Disulfide bridge:Cys2-Cys6) |
Sequence(3-letter code) | DOTA-{p-Cl-Phe}-D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys-D-Tyr-NH2(Disulfide bridge:Cys2-Cys6) |
Peptide Structure | |
Molecular Formula | C69H93ClN16O19S2 |
Molecular Weight | 1550.16 |
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上海鴻肽生物科技有限公司
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郵箱:sales1@hongtide.com
關(guān)鍵字: 1192362-32-5;DOTA-LM3;生長抑素受體(SSTR)拮抗劑多肽DOT;多肽;多肽合成;
上海鴻肽生物科技有限公司(簡稱:鴻肽生物)是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋:定制多肽、目錄多肽、氨基酸衍生物、小分子化合物;公司自成立以來,秉持“用質(zhì)量作船, 以服務(wù)為帆,為科研服務(wù)”的企業(yè)理念,為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。