Beta 2-Microglobulin產(chǎn)品信息

英文名稱：Beta-2-microglobulin

中文名稱：β2微球蛋白

靶點(diǎn)別稱：B2M，Beta-2-Microglobulin

物種：Human / Cynomolgus / Rhesus macaque

標(biāo)簽：His Tag

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>98% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Beta 2-Microglobulin分子背景

β2微球蛋白也稱為β2-微球蛋白（B2M），是MHC I類分子的一種成分，屬于β-2-微球蛋白家族。B2M存在于所有有核細(xì)胞上（不包括紅細(xì)胞）。B2M不僅與MHC I類分子的α鏈結(jié)合，還與CD1和Qa等I類分子結(jié)合。B2M的另一個(gè)功能是與HFE蛋白結(jié)合，共同調(diào)節(jié)肝臟中hepcidin的表達(dá)，hepcidin靶向腸上皮細(xì)胞和巨噬細(xì)胞細(xì)胞質(zhì)膜上的鐵轉(zhuǎn)運(yùn)蛋白ferroportin進(jìn)行降解，分別導(dǎo)致食物中鐵吸收減少和循環(huán)紅細(xì)胞鐵釋放減少。這種功能的喪失會(huì)導(dǎo)致鐵過(guò)量和血色素沉著癥。B2M缺陷是高分解性低蛋白血癥（HYCATHYP）的原因。