IFN-alpha/beta R2產(chǎn)品信息
物種:Human / Mouse / Rat
屬性:Protein
標(biāo)記:Unconjugated
分子別名(Synonym)
IFNAR2,IFNARB,IFNABR,IFN-R-2,IFN-alpha,beta receptor 2
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
IFN-alpha/beta R2分子背景
干擾素α/β受體2(IFNAR2)也稱為IFNα結(jié)合蛋白、IFNα/β接收器2、I型干擾素受體2、IFNABR和IFNARB,后者是一種單程I型膜蛋白,屬于II型細(xì)胞因子受體家族。IFNAR2可以與IFNAR1結(jié)合形成I型干擾素受體。IFNAR2是干擾素α和β的受體。IFNAR2參與IFN介導(dǎo)的STAT1、STAT2和STAT3激活。IFNAR2的異構(gòu)體1和異構(gòu)體2由于與TYR激酶JAK1的關(guān)聯(lián)而直接參與信號轉(zhuǎn)導(dǎo)。IFNAR2的異構(gòu)體3是I型IFN受體活性的強效抑制劑。IFNAR2的遺傳變異影響乙型肝炎病毒(HBV)感染的易感性。
關(guān)鍵字: IFN-alpha/beta R2;IFN-alpha;IFN-beta R2;IFN-alpha蛋白;IFN-beta R2蛋白;
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