中文名稱尿石素C中文同義詞尿石素C;3,8,9-三羥基-6H-苯并[C]色烯-6-酮英文名稱UrolithinC英文同義詞3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;UrolithinC;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one,3,8,9-trihydroxy-;Uro-C;insulin,Cachannels,Apoptosis,Polyphenols,ROS,mitochondria,anti-diabetic,gut-microbial,ReactiveOxygenSpecies,Inhibitor,EndogenousMetabolite,glucose-dependent,metabolite,CalciumChannel,β-cells,UrolithinC,ERK1/2,Ca2+channels,inhibit;UrolithinC(synthetic)CAS號165393-06-6分子式C13H8O5分子量244.2EINECS號相關(guān)類別對照品;HR140137Mol文件165393-06-6.mol結(jié)構(gòu)式尿石素C性質(zhì)熔點>300°C沸點605.4±55.0°C(Predicted)密度1.640±0.06g/cm3(Predicted)儲存條件Inertatmosphere,RoomTemperature溶解度可溶于DMSO（輕微）、甲醇（輕微、加熱）酸度系數(shù)(pKa)7.51±0.20(Predicted)形態(tài)固體顏色灰白色至淺棕色穩(wěn)定性吸濕性LogP1.615(est)尿石素C用途與合成方法生物活性UrolithinC，是鞣花酸的多酚類腸道微生物代謝產(chǎn)物，是胰島素分泌(insulinsecretion)的葡萄糖依賴性激活劑。UrolithinC是一種L型Ca2+通道開放劑，可增強Ca2+的流入。UrolithinC通過線粒體介導(dǎo)的途徑誘導(dǎo)細胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。靶點InsulinsecretionL-typeCa2+channelReactiveoxygenspecies(ROS)Apoptosis體外研究UrolithinC(20-100μM;1hour;INS-1cells)treatmentenhancesglucose-inducedextracellularsignal-regulatedkinases1/2(ERK1/2)activationinINS-1β-cells.UrolithinCsignificantlyinhibitstheproliferationofPC12cells.UrolithinCtreatmentactivelyincreasesthelactatedehydrogenase(LDH)releaseandlipidperoxidationmalondialdehyde(MDA),stimulatesreactiveoxygenspecies(ROS)formationandmitochondrialmembranedepolarization,andcausedcalciumdyshomeostasis.UrolithinCtreatmentinducesapoptosisandSphasecellcyclearrest.WesternBlotAnalysisCellLine:INS-1cellsConcentration:20μM,100μMIncubationTime:1hourResult:Enhancedglucose-inducedextracellularsignal-regulatedkinases1/2(ERK1/2)activation.體內(nèi)研究ThepharmacokineticsofUrolithinC(10mg/kg;intraperitonealadministration)inmaleWistarrat(140-160g)arestudied.Thehalf-lifeoftheterminalpartis11.3handthetotalclearance(CL/F)is3.41L/h/kg.Theinitialvolumeofdistribution(V1/F)andthesteady-statevolumeofdistribution(Vss/F)are0.831L/kgand55.6L/kg,respectively.安全信息MSDS信息尿石素C價格(試劑級)更新日期產(chǎn)品編號產(chǎn)品名稱CAS編號包裝價格2023/10/26HY-135897UrolithinC5mg620元2023/10/26HY-135897尿石素CUrolithinC165393-06-610mM*1mLinDMSO680元尿石素C上下游產(chǎn)品信息
關(guān)鍵字： 165393-06-6;
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