KLRG1產(chǎn)品信息
英文名稱:Killer cell lectin-like receptor subfamily G member 1
中文名稱:殺傷細(xì)胞凝集素樣受體亞家族G成員1
靶點(diǎn)別稱:KLRG1
物種:Human / Mouse / Cynomolgus
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
KLRG1分子背景
共抑制受體殺傷細(xì)胞凝集素樣受體G1(KLRG1)在NK細(xì)胞和活化的CD8+T細(xì)胞上特異性表達(dá),被認(rèn)為是衰老的標(biāo)志。KLRG1+T細(xì)胞是系統(tǒng)性紅斑狼瘡和類風(fēng)濕性關(guān)節(jié)炎等自身免疫性疾病中慢性組織損傷的主要原因。在腫瘤中,表達(dá)E-鈣粘蛋白或N-鈣粘蛋白的腫瘤細(xì)胞與KLRG1結(jié)合,抑制T和NK細(xì)胞的抗腫瘤活性。因此,KLRG1充當(dāng)免疫檢查點(diǎn)抑制受體。
關(guān)鍵字: KLRG1;KLRG1蛋白;KLRG1重組蛋白;KLRG1抗原;KLRG1靶點(diǎn);
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。