LGR5產(chǎn)品信息
英文名稱(chēng):Leucine-rich repeat-containing G-protein coupled receptor 5
中文名稱(chēng):富含亮氨酸重復(fù)序列的G蛋白偶聯(lián)受體-5
靶點(diǎn)別稱(chēng):LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5
物種:Human / Cynomolgus
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
LGR5分子背景
LGR5(也稱(chēng)為GPR49)是GPCR a類(lèi)視紫紅質(zhì)樣家族的七跨膜蛋白。LGR5和LGR4以高親和力結(jié)合R-敏感蛋白,并通過(guò)增強(qiáng)Wnt誘導(dǎo)的LRP6磷酸化來(lái)介導(dǎo)Wnt/β-catenin信號(hào)傳導(dǎo)的增強(qiáng)。LGR5/RSPO復(fù)合物可以通過(guò)中和兩種跨膜E3連接酶RNF43和ZNRF3來(lái)促進(jìn)Wnt信號(hào)傳導(dǎo)。
關(guān)鍵字: LGR5;LGR5蛋白;GPR49;GPR49蛋白;GPR67;
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