TL1A產(chǎn)品信息

英文名稱：Tumor necrosis factor superfamily member 15

中文名稱：腫瘤壞死因子超家族成員15

靶點(diǎn)別稱：TL1A, VEGI, TNFSF15

物種：人/鼠/食蟹猴/兔等

屬性：重組蛋白/細(xì)胞株

標(biāo)記：Biotin-labeled / Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human TL1A, His Tag (TLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 72- Leu 251 (Accession # O95150-1 ).

Predicted N-terminus: His

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

TNF樣細(xì)胞因子1A（TL1A）及其受體、死亡受體3（DR3）和誘餌受體3（DcR3）分別是TNF和TNF受體蛋白超家族的成員。APC衍生的TL1A與淋巴細(xì)胞DR3的結(jié)合為活化的淋巴細(xì)胞提供了共刺激信號(hào)。DR3信號(hào)不僅影響效應(yīng)淋巴細(xì)胞的增殖活性和細(xì)胞因子的產(chǎn)生，還嚴(yán)重影響調(diào)節(jié)性T細(xì)胞的發(fā)育和抑制功能。然而，DcR3限制了TL1A/DR3復(fù)合物的功能：減弱T細(xì)胞活化并下調(diào)促炎細(xì)胞因子的分泌。與DR3和DcR3一起，TL1A構(gòu)成了一個(gè)細(xì)胞因子系統(tǒng)，積極干擾免疫反應(yīng)的調(diào)節(jié)。

TL1A用戶真實(shí)評(píng)價(jià)