Product Name：Pancreatic Polypeptide,human
CAS No.：75976-10-2；59763-91-6
Synonyms：胰腺分泌多肽
Catalog No.：193P02
Brand：HongTide（上海鴻肽生物）
Description：Pancreatic Polypeptide, human 是一種 C 端酰胺化的36個氨基酸肽，可作為神經(jīng)肽 Y (NPY) Y4/Y5 受體激動劑。人胰多肽 (hPP) 就是這樣一種肽，餐后根據(jù)熱量負荷、食物消耗和晝夜節(jié)律從胰島的 F 細胞中釋放出來。 它是一種 C 端酰胺化的 36 個氨基酸肽，具有特征性的發(fā)夾樣胰腺多肽 (PP) 折疊，作用于 Y4 受體以誘導(dǎo)飽腹感并延遲胃排空和運動。 添加人胰腺多肽 (hPP) (10 nM-1 μM) 導(dǎo)致基礎(chǔ)釋放和受激釋放顯著的劑量依賴性降低。 人胰多肽 (hPP) 還可以抑制基礎(chǔ)和刺激的 NPY 釋放，其藥理學特征表明 Y4 突觸前受體的作用。
Pancreatic Polypeptide, human, is a C-terminal amidated 36 amino acid peptide that can serve as a neuropeptide Y (NPY) Y4/Y5 receptor agonist. Human pancreatic peptide (hPP) is such a peptide that is released from the F cells of the pancreas after meals based on calorie load, food consumption, and circadian rhythm. It is a C-terminal amidated 36 amino acid peptide with characteristic hairpin like pancreatic peptide (PP) folding that acts on the Y4 receptor to induce satiety and delay gastric emptying and movement. Adding human pancreatic peptide (hPP) (10 nM-1) μ M) Resulting in a significant dose-dependent decrease in basal and stimulated release. Human pancreatic peptide (hPP) can also inhibit the release of basal and stimulated NPY, and its pharmacological characteristics indicate the role of Y4 presynaptic receptors.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 |
Sequence(3-letter code) | H-Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
Peptide Structure | 
|
Molecular Formula | C185H287N53O54S2 |
Molecular Weight | 4181.8 |
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關(guān)鍵字： Pancreatic Polypepti;59763-91-6;75976-10-2;胰腺分泌多肽;多肽;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。