中文名：Tempol

英文名：Tempol

純度：10mM in DMSO

貨號(hào)：T407895

包裝：1ml

Cas號(hào)：2226-96-2

存儲(chǔ)溫度：-80℃儲(chǔ)存

產(chǎn)品介紹：

Information

Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In?vitro

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. ^[1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. ^[2]

In?vivo

Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. ^[3] Tempol prevents cerebral vessel remodeling in hypertensive rats. ^[4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. ^[5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. ^[6]
Cell?Data

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