中文名：制霉菌素(Fungicidin)
英文名：Nystatin (Fungicidin)
英文別名：Amphotericin B, 8,?9-?dideoxy-?28,?29-?dihydro-?7,?10-?dihydroxy-?35-?O-?(2,?6-?dideoxy-?L-?ribo-?hexopyranosyl)?-
純度：10mM in DMSO
貨號：N408169
包裝：1ml
Cas號：62997-67-5
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Nystatin (Fungicidin) Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
In?vitro
Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six\xa0Candida\xa0species. Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of\xa0endostatin also increases its inhibitory effects on endothelial cell tube formation and migration.
In?vivo
Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. Liposomal\xa0Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group.
Cell?Data
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關(guān)鍵字： Amphotericin B, 8,?9-?dideoxy-?28,?29-?dihydro-?7,?10-?dihydroxy-?35-?O-?(2,?6-?dideoxy-?L-?ribo-?hexopyranosyl)?-
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