中文名：氟西汀 鹽酸鹽

英文名：Fluoxetine (Lilly 110140) HCl

英文別名：N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride

純度：10mM in DMSO

貨號：F408308

包裝：1ml

Cas號：56296-78-7

存儲溫度：-80℃儲存

產(chǎn)品介紹：

Information

Fluoxetine (Lilly 110140) HCl Fluoxetine HCl (Lilly110140) is a selective serotonin -reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
In?vitro

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration.

In?vivo

Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone.
Cell?Data

cell?lines：V-C8 cells

Concentrations：

Incubation?Time：

Powder?Purity:≥99%

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