中文名：雙醋炔諾醇
英文名：Ethynodiol diacetate
英文別名：8080 CB;19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
純度：10mM in DMSO
貨號(hào)：E408955
包裝：1ml
Cas號(hào)：297-76-7
存儲(chǔ)溫度：-80℃儲(chǔ)存
產(chǎn)品介紹：
Information
Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.
In?vitro
Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte.
In?vivo
Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys.
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關(guān)鍵字： 8080 CB;19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
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