中文名：依那普利馬來酸鹽
英文名：Enalapril Maleate
英文別名：MK-421 Maleate;N-?[(1S)?-?1-?(ethoxycarbonyl)?-?3-?phenylpropyl]?-?L-?alanyl-?L-?proline,(2Z)?-?2-?butenedioate (1:1)
純度：10mM in DMSO
貨號：E408277
包裝：1ml
Cas號：76095-16-4
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Enalapril (MK-421) Maleate is anangiotensin-converting enzyme (ACE)inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
In?vitro
Enalapril\xa0is rapidly converted by ester hydrolysis to enalaprilat, a potent ACE\xa0inhibitor;\xa0Enalapril\xa0itself is only a weak ACE\xa0inhibitor.\xa0Enalapril\xa0lowers peripheral vascular resistance without causing an increase in heart rate.\xa0
In?vivo
Enalapril\xa0treatment\xa0abolishes the deleterious effects of\xa0eNOS\xa0deficiency on blood pressure (BP),\xa0atherosclerosis, and\xa0kidney dysfunction\xa0in nnee\xa0mice. Enalapril\xa0causes a dose-dependent increase in fore limb strength\xa0in the\xa0mdx\xa0mouse. Enalapril\xa0causes a dose-dependent reduction of superoxide anion production\xa0in tibialis anterior\xa0muscle\xa0of the\xa0mdx\xa0mouse as observed by dihydroethidium staining.\xa0Enalapril\xa0(5 mg/kg) reduces the area of\xa0muscle\xa0necrosis in both gastrocnemious\xa0muscle\xa0and diaphragm, without significant effect on non-muscle\xa0area. Enalapril Maleate results in significant increases in kidney weight and in concentrations of urinary albumin, N-acetyl-fl-d-glucosamidase (NAG) and serum ET-1 in streptozotocin (STZ)-induced\xa0diabetic (STZ-DM)\xa0rats as compared with the non-diabetic\xa0rats, and the concentration of ET-1 in the kidneys tended to be increased. Enalapril Maleate results in increased mesangial cell proliferation, matrix expansion and enlarged mesangial area in the kidney of the\xa0diabetic\xa0rats.\xa0Enalapril Maleate reduces increased concentrations of urinary albumin and NAG in the STZ-DM\xa0rats to the control values with a slight improvement in the electron microscopic\xa0changes.
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
查看阿拉丁官網(wǎng)此產(chǎn)品相關對應頁面：https://www.aladdin-e.com/zh_cn/E408277.html
關鍵字： MK-421 Maleate;N-?[(1S)?-?1-?(ethoxycarbonyl)?-?3-?phenylpropyl]?-?L-?alanyl-?L-?proline,(2Z)?-?2-?butenedioate (1:1)
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代碼：688179），專注于科研試劑的研發(fā)、生產(chǎn)和銷售，已陸續(xù)建立多個工廠和研發(fā)中心。作為領軍企業(yè)，阿拉丁始終堅持質(zhì)量第一，連續(xù)13年被評為“最受歡迎試劑品牌”。
阿拉丁目前常備庫存試劑產(chǎn)品品種超過7萬種，SKU總數(shù)超過46萬，產(chǎn)品線涵蓋了化學試劑、生化試劑、藥靶配體、蛋白質(zhì)和抗體等多個領域，是國內(nèi)少數(shù)化學試劑到生物試劑全面發(fā)展的國產(chǎn)試劑品牌，產(chǎn)品同步發(fā)布在我們國內(nèi)外電商平臺。