Molecular Formula:
C184H282N50O60S
Relative Molecular Mass:
4186.63 g/mol
CAS-Number:
141758-74-9 (net), 141732-76-5 (Acetate)
Synonyms:
Exendin-4
Sequence:
H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt
Fields of Application:
Diabetes II
Active Substance:
xendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster
(Heloderma suspectum), differs from exendin-3 only in two positions close to the
N-terminus. Application of exenatide causes an increase in acinar cAMP without
stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of
the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged
activity, exenatide augments the postprandial production of insulin and suppresses
secretion of glucagon. Forthis reason, exenatide has found use as a medication
of diabetes II.
關鍵字: 艾塞那肽;醋酸艾塞那肽;Exenatide Acetate;Exenatide